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KMID : 0388220120190020095
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Journal of the Korean Rheumatism Association
2012 Volume.19 No. 2 p.95 ~ p.99
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A Case of Rheumatoid Arthritis in a Patient with Bruton-Type Agammaglobulinemia
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Park Dong-Jin
Lee Sung-Ji
Kim Tae-Jong
Park Yong-Wook
Bae Eun-Sin
Kang Eun-Sook
Lee Shin-Seok
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Abstract
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Bruton-type agammaglobulinemia is primary hypogammaglobulinemia followed by severe recurrent infection, including bacterial otitis media, bronchitis, pneumonia, and meningitis. Septic arthritis is a main musculoskeletal disorder that can occur in association with Bruton-type agammaglobulinemia. But the development of rheumatoid arthritis (RA) is rarely reported in a patient with hypogammaglobulinemia. Here, we describe a case of 34-year-old male with Bruton-type agammaglobulinemia, who presented with multiple symmetric polyarthritis. He was diagnosed as having a RA according to ACR criteria. His symptoms of polyarthritis had been improved after the introduction of medications including DMARDs (disease modifying anti-rheumatic drugs). Our case suggests that RA can be developed in the setting of agammaglobulinemia, and even in this situation, anti-rheumatic agents were effective to control arthritis without complication such as severe infection.
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KEYWORD
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Bruton-type agammaglobulinemia, Rheumatoid arthritis, Anti-rheumatic agents
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